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Dawn Bowdish

Dawn Bowdish

Canada Research Chair in Aging and Immunity

Tier 2 2014-09-01




It is unclear why susceptibility to bacterial pneumonia begins to increase in middle
age (i.e 55 yrs); however, these infections become increasingly common and costly to
treat with age. In addition, acquiring bacterial pneumonia in mid- or late life often
exacerbates or accelerates sub-clinical or existing chronic inflammatory conditions,
decreasing the quality of life and increasing the cost of care. This proposal
investigates the mechanisms of susceptibility to the major causative agent of
pneumonia in the elderly, Streptococcus pneumoniae, and the interplay between ageassociated
inflammation, chronic inflammatory diseases and the anti-bacterial
response, targeting age-associated inflammation as a novel therapeutic target.