Canada Research Chair in Bioseparations Engineering
Tier 2 - 2005-03-01
RESEARCH INVOLVESBioseparations engineering, membrane science and technology, protein purification, and membrane bioreactors.
RESEARCH RELEVANCEThe research involves research on protein bioseparations using membrane-based technologies.
NEW INNOVATIONS IN CANADA'S BIO-INDUSTRY: REDUCING THE COST OF BIOPRODUCTS USING MEMBRANE-BASED TECHNOLOGIESBioseparations engineering involves the large-scale purification of products synthesized by fermentation, cell culture, and other biological processes. Proteins represent the largest category of commercialized bioproducts.
Bioseparations engineering of proteins is technically difficult and expensive, particularly in cases where the bioproducts are intended for pharmaceutical, nutraceutical, or diagnostic applications. The cost of bioseparation is frequently as high as 60 to 80 percent of the total cost of production for bioproducts such as monoclonal antibodies, therapeutic proteins, hormones, and growth factors. Not surprisingly, these products tend to be very expensive and, frequently, this is the major obstacle to their wider acceptance and use.
The success of biotechnology based pharmaceutical products, particularly those that do not enjoy patent protection (i.e., generic products), quite often depends on how inexpensively they can be made. Membrane-based bioseparation technologies can create quality products in a cost-effective manner, and research and development work in this field is destined to have a significant impact on the growth of the bio-industry in Canada
McMaster chemical engineer, Canada Research Chair Raja Ghosh works in the area of protein bioseparations engineering. He uses a variety of membrane technologies including ultrafiltration, membrane chromatography, and integrated bioseparations. His work is expected to cut down the cost of production of bioproducts, and thus making certain important health-care products more affordable and widely available.