Geoffrey Brian Golding
Canada Research Chair in Bioinformatics
Tier 1 - 2002-07-01 Renewed: 2009-09-01
RESEARCH INVOLVESExploration of the nature of the changes observed between molecules, between genes and between genomes.
RESEARCH RELEVANCEGenomics and Bioinformatics have the potential to revolutionize the fields of health and environmental research, and have an impact in such areas as molecular medicine, infectious diseases and agriculture.
MAKING SENSE OF GENOMICS DATARecent technological advances in molecular genetics provide a storm of new data on DNA sequences, gene structure, gene expression and higher order genomic structure. These data are in such quantities that they can be produced much faster than they can be analyzed by traditional techniques. Bioinformatics is a new, multi-disciplinary field combining biology, computer science and mathematics to analyze data generated by genomics and to extract knowledge from it.
Dr. Geoffrey Brian Golding, whose work spans fields as diverse as functional proteomics and molecular evolution, is Canada Research Chair in Bioinformatics at McMaster University. The long-term objectives of his research program are to determine the patterns and mechanisms of molecular evolution and influences of the natural processes of mutation, gene transfer, and selection on sequence evolution. An understanding of these processes is central to making use of the molecular information obtained from genome studies, and to understanding the data that will become available from large-scale studies of environmental genomics.
One of Dr. Golding's four current projects involves the study of horizontal gene transfer, now recognized as a major factor of bacterial evolution, and the principle means by which antibiotic resistance genes spread. He is also making investigations into the rates and patterns of substitutions, research that is ultimately of great interest to the pharmaceutical industry. Other major projects include the study genome-wide structural properties of proteins and prokaryotic genome studies.
Bioinformatics has the potential to lead to fascinating and exciting discoveries. With the assistance of the Canada Research Chair, Dr. Golding will be instrumental in advancing this new research area, and in training much needed personnel in a field where there is currently a great shortage of expertise.